Cyclooxygenases (COX-1 and COX-2)
 Cyclooxygenase (COX) is an arachidonic acid metabolizing enzyme existing in two isoforms, the constitutive cyclooxygenase-1 (COX-1) and the inducible cyclooxygenase-2 (COX-2). Both isoforms lead to the formation of various eicosanoids involved in several disease states, such as inflammation, fever, arthritis, and, more recently discovered, cancer. The implications of COXs have been studied in various cardiovascular, asthmatic, and inflammatory diseases and cancers. Therefore inhibiting these enzymes represents an advantageous therapeutic strategy. We apply computational techniques to assist the discovery of novel COX-1 and -2 inhibitors and to gain more insight into their mechanism of action. Recent Publications
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